abstract：OBJECTIVES:The purpose of this study was to assess myocardial blood flow (MBF) using positron emission tomography in patients with hypertrophic cardiomyopathy (HCM) according to genetic status. BACKGROUND:Coronary microvascular dysfunction is an important feature of HCM, associated with ventricular remodeling and hear...

journal_title：Journal of the American College of Cardiology

authors： Olivotto I,Girolami F,Sciagrà R,Ackerman MJ,Sotgia B,Bos JM,Nistri S,Sgalambro A,Grifoni C,Torricelli F,Camici PG,Cecchi F

更新日期：2011-08-16 00:00:00

abstract：:Peripartum cardiomyopathy is a pregnancy-associated myocardial disease characterized by the development of heart failure due to marked left ventricular systolic dysfunction. Although the disease is relatively uncommon, its incidence is increasing, and it can be associated with important and lasting morbidity and with ...

journal_title：Journal of the American College of Cardiology

authors： Elkayam U

更新日期：2011-08-09 00:00:00

abstract：OBJECTIVES:We compared the safety of different devices by screening for subclinical intracranial embolic events after pulmonary vein isolation with either conventional irrigated radiofrequency (RF) or cryoballoon or multielectrode phased RF pulmonary vein ablation catheter (PVAC). BACKGROUND:New devices specifically d...

journal_title：Journal of the American College of Cardiology

authors： Herrera Siklódy C,Deneke T,Hocini M,Lehrmann H,Shin DI,Miyazaki S,Henschke S,Fluegel P,Schiebeling-Römer J,Bansmann PM,Bourdias T,Dousset V,Haïssaguerre M,Arentz T

更新日期：2011-08-09 00:00:00

abstract：:With the emergence of new lipid risk markers and a growing cardiometabolic risk burden in the United States, there is a need to better integrate residual risk into cardiovascular disease (CVD) risk stratification. In anticipation of the Adult Treatment Panel IV (ATP IV) guidelines from the National Cholesterol Educati...

journal_title：Journal of the American College of Cardiology

authors： Ramjee V,Sperling LS,Jacobson TA

更新日期：2011-07-26 00:00:00

abstract：OBJECTIVES:The purpose of this study was to determine whether high-intensity carotid plaques visualized by a noncontrast T1-weighted imaging technique, magnetization-prepared rapid acquisition with gradient echo (MPRAGE), predict future coronary events in patients with clinically stable coronary artery disease (CAD). ...

journal_title：Journal of the American College of Cardiology

authors： Noguchi T,Yamada N,Higashi M,Goto Y,Naito H

更新日期：2011-07-19 00:00:00

abstract：:To varying extents, women with pre-existing cardiomyopathies have a limited cardiovascular reserve. The hemodynamic challenges of pregnancy, labor, and delivery pose unique risks to this group of patients, which can result in clinical decompensation with overt heart failure, arrhythmias, and rarely, maternal death. A ...

journal_title：Journal of the American College of Cardiology

authors： Stergiopoulos K,Shiang E,Bench T

更新日期：2011-07-19 00:00:00

abstract：OBJECTIVES:The purpose of the study was to assess the cardiovascular risk of impaired fasting glucose (IFG). BACKGROUND:The associations between IFG, incident type 2 diabetes mellitus (T2DM), and cardiovascular (CV) events remains unclear. METHODS:The MESA (Multi-Ethnic Study of Atherosclerosis) study included partic...

journal_title：Journal of the American College of Cardiology

authors： Yeboah J,Bertoni AG,Herrington DM,Post WS,Burke GL

更新日期：2011-07-05 00:00:00

abstract：OBJECTIVES:We aimed to compare the predictive capabilities of N-terminal pro-brain natriuretic peptide (NT-proBNP) and C-reactive protein (CRP) for risk of cardiovascular disease (CVD) in older men with and without pre-existing CVD. BACKGROUND:The clinical utility of NT-proBNP in CVD risk stratification in the general...

journal_title：Journal of the American College of Cardiology

authors： Wannamethee SG,Welsh P,Lowe GD,Gudnason V,Di Angelantonio E,Lennon L,Rumley A,Whincup PH,Sattar N

更新日期：2011-06-28 00:00:00

abstract：:Coronary heart disease remains a major cause of morbidity and mortality in the United States, and its incidence is rising worldwide. Because atherosclerosis is a chronic process, and it is often associated with certain lifestyle and risk factors such as hypertension, dyslipidemia, and insulin resistance, much emphasis...

journal_title：Journal of the American College of Cardiology

authors： Gobal F,Deshmukh A,Shah S,Mehta JL

更新日期：2011-06-07 00:00:00

abstract：OBJECTIVES:This study sought to describe the clinical correlates and heritability of the early repolarization pattern (ERP) in 2 large, population-based cohorts. BACKGROUND:There is growing recognition that ERP is associated with adverse outcomes. METHODS:Participants of the Framingham Heart Study (FHS) (N = 3,995) a...

journal_title：Journal of the American College of Cardiology

authors： Noseworthy PA,Tikkanen JT,Porthan K,Oikarinen L,Pietilä A,Harald K,Peloso GM,Merchant FM,Jula A,Väänänen H,Hwang SJ,O'Donnell CJ,Salomaa V,Newton-Cheh C,Huikuri HV

更新日期：2011-05-31 00:00:00

abstract：OBJECTIVES:The aim of this study was to compare treatment effects of drug-eluting stents (DES) or coronary artery bypass grafting (CABG) for left main coronary artery (LMCA) disease according to the complexity of atherosclerotic disease burden. BACKGROUND:Limited information is available on the relationships between t...

journal_title：Journal of the American College of Cardiology

authors： Park DW,Kim YH,Yun SC,Song HG,Ahn JM,Oh JH,Kim WJ,Lee JY,Kang SJ,Lee SW,Lee CW,Park SW,Park SJ

更新日期：2011-05-24 00:00:00

abstract：OBJECTIVES:This study tested the hypothesis that activation of adenylyl cyclase 6 (AC6) expression in cardiac myocytes improves calcium uptake and left ventricular (LV) function in aging mice. BACKGROUND:Aging hearts exhibit impaired β-adrenergic receptor signaling and LV dysfunction. METHODS:Twenty-month-old mice wi...

journal_title：Journal of the American College of Cardiology

authors： Tang T,Hammond HK,Firth A,Yang Y,Gao MH,Yuan JX,Lai NC

更新日期：2011-05-03 00:00:00

abstract：OBJECTIVES:The aim of this study was to characterize the relationship between pericardial fat and atrial fibrillation (AF). BACKGROUND:Obesity is an important risk factor for AF. Pericardial fat has been hypothesized to exert local pathogenic effects on nearby cardiac structures above and beyond that of systemic adipo...

journal_title：Journal of the American College of Cardiology

authors： Wong CX,Abed HS,Molaee P,Nelson AJ,Brooks AG,Sharma G,Leong DP,Lau DH,Middeldorp ME,Roberts-Thomson KC,Wittert GA,Abhayaratna WP,Worthley SG,Sanders P

更新日期：2011-04-26 00:00:00

abstract：OBJECTIVES:The aim of this study was to identify the remodeling parameters cardiomyocyte (CM) damage or death, hypertrophy, and fibrosis that may be linked to outcomes in patients with advanced heart failure (HF) in an effort to understand the pathogenic mechanisms of HF that may support newer therapeutic modalities. ...

journal_title：Journal of the American College of Cardiology

authors： Vigliano CA,Cabeza Meckert PM,Diez M,Favaloro LE,Cortés C,Fazzi L,Favaloro RR,Laguens RP

更新日期：2011-04-05 00:00:00

abstract：:The prevalence of atrial fibrillation (AF) in end-stage renal failure is high, with an increased risk of stroke among these patients with AF compared with the AF population without severe renal impairment. Many trials have shown the net clinical benefit of oral anticoagulation therapy for primary and secondary prevent...

journal_title：Journal of the American College of Cardiology

authors： Marinigh R,Lane DA,Lip GY

更新日期：2011-03-22 00:00:00

abstract：OBJECTIVES:The purpose of this study was to determine whether cilostazol reduces intimal hyperplasia in patients undergoing long zotarolimus-eluting stent implantation (stent length: ≥ 30 mm) for native long coronary lesions (length: ≥ 25 mm). BACKGROUND:Restenosis after drug-eluting stent implantation remains a signi...

journal_title：Journal of the American College of Cardiology

authors： Lee SW,Park SW,Kim YH,Yun SC,Park DW,Lee CW,Kang SJ,Park SJ,Lee JH,Choi SW,Seong IW,Lee NH,Cho YH,Shin WY,Lee SJ,Lee SW,Hyon MS,Bang DW,Choi YJ,Kim HS,Lee BK,Lee K,Park HK,Park CB,Lee SG,Kim MK,Park KH

更新日期：2011-03-15 00:00:00

abstract：OBJECTIVES:This study aimed to investigate sex differences in the association between arterial stiffness and left ventricular (LV) diastolic dysfunction. BACKGROUND:Heart failure with preserved ejection fraction is more common in women. Arterial stiffness has been suggested as a significant contributor to the developm...

journal_title：Journal of the American College of Cardiology

authors： Shim CY,Park S,Choi D,Yang WI,Cho IJ,Choi EY,Chung N,Ha JW

更新日期：2011-03-08 00:00:00

abstract：OBJECTIVES:The aim of this paper was to study mechanisms of formation of fractionated electrograms on the posterior left atrial wall (PLAW) in human paroxysmal atrial fibrillation (AF). BACKGROUND:The mechanisms responsible for complex fractionated atrial electrogram formation during AF are poorly understood. METHODS...

journal_title：Journal of the American College of Cardiology

authors： Atienza F,Calvo D,Almendral J,Zlochiver S,Grzeda KR,Martínez-Alzamora N,González-Torrecilla E,Arenal A,Fernández-Avilés F,Berenfeld O

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVES:The objective of this study was to evaluate the effects of different lesion sets of ablation in patients undergoing mitral surgery plus maze. BACKGROUND:The role of lesion sets on outcome after maze is poorly defined. METHODS:A total of 141 patients were prospectively followed up. Two different lesion sets...

journal_title：Journal of the American College of Cardiology

authors： Onorati F,Mariscalco G,Rubino AS,Serraino F,Santini F,Musazzi A,Klersy C,Sala A,Renzulli A

更新日期：2011-02-22 00:00:00

abstract：OBJECTIVES:This study tried to determine the association between left atrial (LA) fibrosis, detected using delayed-enhanced magnetic resonance imaging (DE-MRI), and the CHADS(2) score (point system based on individual clinical risk factors including congestive heart failure, hypertension, age, diabetes, and prior strok...

journal_title：Journal of the American College of Cardiology

authors： Daccarett M,Badger TJ,Akoum N,Burgon NS,Mahnkopf C,Vergara G,Kholmovski E,McGann CJ,Parker D,Brachmann J,Macleod RS,Marrouche NF

更新日期：2011-02-15 00:00:00

abstract：:High-risk plaques that are vulnerable to rupture demonstrate distinct morphological characteristics. They are differentiated from the lesions responsible for stable coronary artery disease by their large necrotic cores, thin-inflamed fibrous caps, and positive remodeling. Adiponectin is an adipocytokine that is reduce...

journal_title：Journal of the American College of Cardiology

authors： Barseghian A,Gawande D,Bajaj M

更新日期：2011-02-15 00:00:00

abstract：OBJECTIVES:This study was designed to test the effects of n-3 polyunsaturated fatty acids (PUFAs) on left ventricular (LV) systolic function in chronic heart failure (HF) due to nonischemic dilated cardiomyopathy (NICM). BACKGROUND:One hundred thirty-three patients with NICM and minimal symptoms on standard therapy we...

journal_title：Journal of the American College of Cardiology

authors： Nodari S,Triggiani M,Campia U,Manerba A,Milesi G,Cesana BM,Gheorghiade M,Dei Cas L

更新日期：2011-02-15 00:00:00

abstract：OBJECTIVES:The purpose of this study is to evaluate the efficacy and safety of ticagrelor and clopidogrel in patients with acute coronary syndrome undergoing coronary artery bypass graft surgery (CABG), as a post-randomization strategy. BACKGROUND:Ticagrelor is a novel, reversibly binding, oral, direct-acting P2Y(12)-...

journal_title：Journal of the American College of Cardiology

authors： Held C,Asenblad N,Bassand JP,Becker RC,Cannon CP,Claeys MJ,Harrington RA,Horrow J,Husted S,James SK,Mahaffey KW,Nicolau JC,Scirica BM,Storey RF,Vintila M,Ycas J,Wallentin L

更新日期：2011-02-08 00:00:00

abstract：OBJECTIVES:We evaluated the efficacy and safety of the percutaneous ventricular assist device (pVAD) in patients in severe refractory cardiogenic shock (SRCS) despite intra-aortic balloon pump (IABP) and/or high-dose vasopressor support. BACKGROUND:SRCS is associated with substantial mortality despite IABP counterpuls...

journal_title：Journal of the American College of Cardiology

authors： Kar B,Gregoric ID,Basra SS,Idelchik GM,Loyalka P

更新日期：2011-02-08 00:00:00

abstract：OBJECTIVES:We hypothesized that women with lower extremity peripheral arterial disease (PAD) would have greater mobility loss and faster functional decline than men with PAD. BACKGROUND:Whether rates of mobility loss or functional decline differ between men and women with PAD is currently unknown. METHODS:Three hundr...

journal_title：Journal of the American College of Cardiology

authors： McDermott MM,Ferrucci L,Liu K,Guralnik JM,Tian L,Kibbe M,Liao Y,Tao H,Criqui MH

更新日期：2011-02-08 00:00:00

abstract：OBJECTIVES:The purpose of this study was to determine the risk of adverse cardiovascular events associated with concomitant use of clopidogrel and calcium-channel blockers (CCBs) in patients with myocardial infarction (MI). BACKGROUND:CCBs inhibit a variety of cytochrome P-450 enzymes, some of which contribute to clop...

journal_title：Journal of the American College of Cardiology

authors： Olesen JB,Gislason GH,Charlot MG,Fosbøl EL,Andersson C,Weeke P,Ahlehoff O,Selmer C,Torp-Pedersen C,Hansen PR

更新日期：2011-01-25 00:00:00

abstract：OBJECTIVES:the purpose of this study was to evaluate the association of the percentage of platelet inhibitory response to clopidogrel as assessed by modified thromboelastography with bleeding and transfusion requirement after off-pump coronary artery bypass graft (OPCABG) surgery. BACKGROUND:Interindividual variabilit...

journal_title：Journal of the American College of Cardiology

authors： Kwak YL,Kim JC,Choi YS,Yoo KJ,Song Y,Shim JK

更新日期：2010-12-07 00:00:00

abstract：OBJECTIVES:we tested the hypothesis that bi-directional, gene-targeted regulation of cardiomyocyte cyclic guanosine monophosphate-selective phosphodiesterase type 5 (PDE5) influences maladaptive remodeling in hearts subjected to sustained pressure overload. BACKGROUND:PDE5 expression is up-regulated in human hypertrop...

journal_title：Journal of the American College of Cardiology

authors： Zhang M,Takimoto E,Hsu S,Lee DI,Nagayama T,Danner T,Koitabashi N,Barth AS,Bedja D,Gabrielson KL,Wang Y,Kass DA

更新日期：2010-12-07 00:00:00

abstract：OBJECTIVES:We examined the effect of asialoerythropoietin (asialoEPO), a nonerythrogenic derivative of erythropoietin (EPO), on renal dysfunction-associated heart failure. BACKGROUND:Although EPO is known to exert beneficial effects on cardiac function, the clinical benefits in patients with chronic kidney disease are...

journal_title：Journal of the American College of Cardiology

authors： Ogino A,Takemura G,Kawasaki M,Tsujimoto A,Kanamori H,Li L,Goto K,Maruyama R,Kawamura I,Takeyama T,Kawaguchi T,Watanabe T,Moriguchi Y,Saito H,Fujiwara T,Fujiwara H,Minatoguchi S

更新日期：2010-11-30 00:00:00

abstract：OBJECTIVES:the aim of this study was to determine whether telmisartan decreases all-cause and cardiovascular mortality and morbidity in hemodialysis patients with chronic heart failure (CHF) and impaired left ventricular ejection fraction (LVEF) when added to standard therapies with angiotensin-converting enzyme inhibi...

journal_title：Journal of the American College of Cardiology

authors： Cice G,Di Benedetto A,D'Isa S,D'Andrea A,Marcelli D,Gatti E,Calabrò R

更新日期：2010-11-16 00:00:00

abstract：:Baseline coronary artery calcification (CAC) accurately identifies coronary atherosclerosis and might improve prediction of future cardiac events. Serial assessment of CAC scores has been proposed for monitoring atherosclerosis progression and for assessing the effectiveness of medical therapies aimed at reducing card...

journal_title：Journal of the American College of Cardiology

authors： McEvoy JW,Blaha MJ,Defilippis AP,Budoff MJ,Nasir K,Blumenthal RS,Jones SR

更新日期：2010-11-09 00:00:00

abstract：OBJECTIVES:The purpose of this study was to investigate the long-term outcome after elective percutaneous coronary intervention in low-risk patients screened for aspirin and/or clopidogrel responsiveness in the 3T/2R (Tailoring Treatment With Tirofiban in Patients Showing Resistance to Aspirin and/or Resistance to Clop...

journal_title：Journal of the American College of Cardiology

authors： Campo G,Fileti L,de Cesare N,Meliga E,Furgieri A,Russo F,Colangelo S,Brugaletta S,Ferrari R,Valgimigli M,3T\/2R Investigators.

更新日期：2010-10-26 00:00:00

abstract：OBJECTIVES:The goal of this pre-clinical study was to assess the therapeutic efficacy of doxycycline (Doxy) for desmin-related cardiomyopathy (DRC) and to elucidate the potential mechanisms involved. BACKGROUND:DRC, exemplifying cardiac proteinopathy, is characterized by intrasarcoplasmic protein aggregation and cardi...

journal_title：Journal of the American College of Cardiology

authors： Zheng H,Tang M,Zheng Q,Kumarapeli AR,Horak KM,Tian Z,Wang X

更新日期：2010-10-19 00:00:00

abstract：OBJECTIVES:The primary objective of this study was to assess the effect of a 6-month testosterone supplementation therapy on functional capacity and insulin resistance in female patients with chronic heart failure (CHF). BACKGROUND:Patients with CHF show decreased exercise capacity and insulin sensitivity. Testosteron...

journal_title：Journal of the American College of Cardiology

authors： Iellamo F,Volterrani M,Caminiti G,Karam R,Massaro R,Fini M,Collins P,Rosano GM

更新日期：2010-10-12 00:00:00

abstract：OBJECTIVES:We investigated whether the presence of right ventricular (RV) abnormalities detected by cardiovascular magnetic resonance (CMR) predict adverse outcome in patients presenting with frequent premature ventricular complexes (PVCs) of left bundle branch block (LBBB) morphology. BACKGROUND:CMR is a component of...

journal_title：Journal of the American College of Cardiology

authors： Aquaro GD,Pingitore A,Strata E,Di Bella G,Molinaro S,Lombardi M

更新日期：2010-10-05 00:00:00

abstract：:Circulating biomarkers have become increasingly important in diagnosing and risk stratifying patients with heart failure (HF). While the natriuretic peptides have received much focus, there is increasing interest in the role of circulating cardiac troponin (cTn) in detecting myocardial injury (often subclinical) in th...

journal_title：Journal of the American College of Cardiology

authors： Kociol RD,Pang PS,Gheorghiade M,Fonarow GC,O'Connor CM,Felker GM

更新日期：2010-09-28 00:00:00

abstract：OBJECTIVES:We aimed to investigate whether clopidogrel-induced inhibition of platelet reactivity could reduce the level of circulating endothelial cells (CEC), reflecting the endothelial injury induced by percutaneous coronary intervention (PCI). BACKGROUND:Clopidogrel loading dose before percutaneous coronary angiopl...

journal_title：Journal of the American College of Cardiology

authors： Bonello L,Harhouri K,Sabatier F,Camoin-Jau L,Arnaud L,Baumstarck-Barrau K,Ait-Mokhtar O,Roubille F,Piot C,Lesavre N,Paganelli F,Dignat-George F

更新日期：2010-09-21 00:00:00

abstract：OBJECTIVES:The purpose of this study was to assess the value of implantable cardioverter-defibrillator (ICD) electrograms (EGMs) in identifying clinically documented ventricular tachycardias (VTs). BACKGROUND:Twelve-lead electrocardiograms (ECG) of spontaneous VT often are not available in patients referred for cathet...

journal_title：Journal of the American College of Cardiology

authors： Yoshida K,Liu TY,Scott C,Hero A,Yokokawa M,Gupta S,Good E,Morady F,Bogun F

更新日期：2010-09-14 00:00:00

abstract：:The prevalence of atrial fibrillation (AF) is related to age and is projected to rise exponentially as the population ages and the prevalence of cardiovascular risk factors increases. The risk of ischemic stroke is significantly increased in AF patients, and there is evidence of a graded increased risk of stroke assoc...

journal_title：Journal of the American College of Cardiology

authors： Marinigh R,Lip GY,Fiotti N,Giansante C,Lane DA

更新日期：2010-09-07 00:00:00

abstract：OBJECTIVES:We sought to establish the prognostic value of a comprehensive cardiovascular magnetic resonance (CMR) examination in risk stratification of hypertrophic cardiomyopathy (HCM) patients. BACKGROUND:With annual mortality rates ranging between 1% and 5%, depending on patient selection, a small but significant n...

journal_title：Journal of the American College of Cardiology

authors： Bruder O,Wagner A,Jensen CJ,Schneider S,Ong P,Kispert EM,Nassenstein K,Schlosser T,Sabin GV,Sechtem U,Mahrholdt H

更新日期：2010-09-07 00:00:00